Mecom^tm1.1Fcam
Targeted Allele Detail

Summary

• Symbol: Mecom^tm1.1Fcam
• Name: MDS1 and EVI1 complex locus; targeted mutation 1.1, Fernando D Camargo
• MGI ID: MGI:6729236
• Synonyms: Mds1^GFP
• Gene: Mecom Location: Chr3:30005445-30563937 bp, - strand Genetic Position: Chr3, 12.66 cM
• Alliance: Mecom^tm1.1Fcam page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:292941
• Parent Cell Line: v6.5 (ES Cell)
• Strain of Origin: (C57BL/6 x 129S4/SvJae)F1

Mutation description

• Allele Type: Targeted (Conditional ready, Reporter)
• Mutation: Insertion
• Mutation details: An M2rtTA/IRES, loxP flanked GFP, polyA, and an FRT-flanked neomycin cassette were introduced immediately after the ATG codon in exon 1 of the mouse Mecom gene via homologous recombination in embryonic stem (ES) cells. The resultant mice were crossed with Flp-expressing mice to remove the selection cassette. (J:292941)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Mecom Mutation: 82 strains or lines available

References

• Original: J:292941 Christodoulou C, et al., Live-animal imaging of native haematopoietic stem and progenitor cells. Nature. 2020 Feb;578(7794):278-283
• All: 1 reference(s)