Cd4^tm1.1Arah
Targeted Allele Detail

Summary

• Symbol: Cd4^tm1.1Arah
• Name: CD4 antigen; targeted mutation 1.1, Amin Rahemtulla
• MGI ID: MGI:6728831
• Synonyms: CD4deltasil, Cd4Sil^f
• Gene: Cd4 Location: Chr6:124841655-124865184 bp, - strand Genetic Position: Chr6, 59.17 cM
• Alliance: Cd4^tm1.1Arah page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:295204
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Constitutively active)
• Mutation: Intragenic deletion
• Mutation details: A silencer in intron 1 was replaced with a loxP site flanked neomycin resistance gene cassette. The neo cassette was removed through subsequent cre-mediated recombination. (J:295204)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Cd4 Mutation: 84 strains or lines available

References

• Original: J:295204 Leung RK, et al., Deletion of the CD4 silencer element supports a stochastic mechanism of thymocyte lineage commitment. Nat Immunol. 2001 Dec;2(12):1167-73
• All: 2 reference(s)