Pdgfrb^tm11.1Sor
Targeted Allele Detail

Summary

• Symbol: Pdgfrb^tm11.1Sor
• Name: platelet derived growth factor receptor, beta polypeptide; targeted mutation 11.1, Philippe Soriano
• MGI ID: MGI:6728536
• Gene: Pdgfrb Location: Chr18:61178222-61218133 bp, + strand Genetic Position: Chr18, 34.41 cM
• Alliance: Pdgfrb^tm11.1Sor page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:306160
• Parent Cell Line: AK7 (ES Cell)
• Strain of Origin: 129S4/SvJaeSor

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: LoxP sites were inserted at a BstEII and a HpaI site about 500 base pairs upstream of and 2,100 base pairs downstream from the exons encoding the first and second immunoglobulin domain, respectively. Additionally, a FRT-flanked PGKneo cassette was inserted and then removed by crossing with Gt(ROSA)26Sor^tm1(FLP1)Dym mice. Cre-mediated recombination removed the floxed segment. (J:306160)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Pdgfrb Mutation: 89 strains or lines available

References

• Original: J:306160 Sun C, et al., Mosaic Mutant Analysis Identifies PDGFRalpha/PDGFRbeta as Negative Regulators of Adipogenesis. Cell Stem Cell. 2020 May 7;26(5):707-721.e5
• All: 1 reference(s)