Pdgfra^tm8.1Sor
Targeted Allele Detail

Summary

• Symbol: Pdgfra^tm8.1Sor
• Name: platelet derived growth factor receptor, alpha polypeptide; targeted mutation 8.1, Philippe Soriano
• MGI ID: MGI:6728535
• Gene: Pdgfra Location: Chr5:75312953-75358876 bp, + strand Genetic Position: Chr5, 39.55 cM
• Alliance: Pdgfra^tm8.1Sor page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:306160
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A loxP site was introduced upstream of exon 1 and a PGK-neo-loxP cassette was introduced downstream of exon 4 via homologous recombination. Cre-mediated recombination removed exon 1. (J:306160)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Pdgfra Mutation: 88 strains or lines available

References

• Original: J:306160 Sun C, et al., Mosaic Mutant Analysis Identifies PDGFRalpha/PDGFRbeta as Negative Regulators of Adipogenesis. Cell Stem Cell. 2020 May 7;26(5):707-721.e5
• All: 1 reference(s)