Otop1^em2Csz
Endonuclease-mediated Allele Detail

Summary

• Symbol: Otop1^em2Csz
• Name: otopetrin 1; endonuclease-mediated mutation 2, Charles S Zuker
• MGI ID: MGI:6728128
• Gene: Otop1 Location: Chr5:38434748-38461560 bp, + strand Genetic Position: Chr5, 20.35 cM
• Alliance: Otop1^em2Csz page

Mutation origin

• Strain of Origin: Not Specified

Mutation description

• Allele Type: Endonuclease-mediated (Null/knockout)
• Mutation: Intragenic deletion
• Mutation details: CRISPR/Cas genome editing technology was used to generate a 49 nucleotide deletion of genomic sequences in exon 1, resulting in early termination in exon 2. Two founders were generated with no differences in experimental observations. The loss of OTOP1 protein in the homozygous mutants was verified by immunostaining using OTOP1 antibodies. (J:293042)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Otop1 Mutation: 38 strains or lines available

References

• Original: J:293042 Zhang J, et al., Sour Sensing from the Tongue to the Brain. Cell. 2019 Oct 3;179(2):392-402.e15
• All: 2 reference(s)