Cnr1^tm1.1Dlp
Targeted Allele Detail

Summary

• Symbol: Cnr1^tm1.1Dlp
• Name: cannabinoid receptor 1; targeted mutation 1.1, Eric Delpire
• MGI ID: MGI:6727057
• Synonyms: CB1^f
• Gene: Cnr1 Location: Chr4:33924593-33948831 bp, + strand Genetic Position: Chr4, 16.28 cM
• Alliance: Cnr1^tm1.1Dlp page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:307907
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: 129S6/SvEvTac

Mutation description

• Allele Type: Targeted (Conditional ready)
• Mutation: Insertion
• Mutation details: A loxP site was inserted 141 bp upstream of exon 2 and an FRT site, loxP site, neomycin-resistance gene cassette, FRT site and a third loxP site were inserted 622 bp downstream of exon 2. Flp-mediated recombination removed the selection cassette leaving exon 2 floxed. (J:307907)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Cnr1 Mutation: 41 strains or lines available

References

• Original: J:307907 Marcus DJ, et al., Endocannabinoid Signaling Collapse Mediates Stress-Induced Amygdalo-Cortical Strengthening. Neuron. 2020 Mar 18;105(6):1062-1076.e6
• All: 5 reference(s)