Macroh2a1^tm1Oxbo
Targeted Allele Detail

Summary

• Symbol: Macroh2a1^tm1Oxbo
• Name: macroH2A.1 histone; targeted mutation 1, Oxana Bereshchenko
• MGI ID: MGI:6726545
• Synonyms: macroH2A1.1^fl
• Gene: Macroh2a1 Location: Chr13:56221435-56283439 bp, - strand Genetic Position: Chr13, 30.06 cM, cytoband B2
• Alliance: Macroh2a1^tm1Oxbo page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:293382
• Parent Cell Line: A9 (ES Cell)
• Strain of Origin: (C57BL/6 x 129P2/OlaHsd)F1

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: A lacZ-neo cassette flanked by loxP and rox sites at the 5' and 3' ends, respectively, was inserted into the intron between exons 6a and 6b. Another rox site was inserted upstream of exon 6a and another loxP site downstream of exon 6b so that dre/rox recombination can remove exon 6a and the lacZ-neo cassette, and cre/loxP recombination can remove exon 6b and the lacZ-neo cassette. (J:293382)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Macroh2a1 Mutation: 49 strains or lines available

References

• Original: J:293382 Bereshchenko O, et al., Deficiency and haploinsufficiency of histone macroH2A1.1 in mice recapitulate hematopoietic defects of human myelodysplastic syndrome. Clin Epigenetics. 2019 Aug 22;11(1):121
• All: 2 reference(s)