Gt(ROSA)26Sor^{tm1(CAG-Axin1,-lacZ)Kini}
Targeted Allele Detail

Summary

• Symbol: Gt(ROSA)26Sor^{tm1(CAG-Axin1,-lacZ)Kini}
• Name: gene trap ROSA 26, Philippe Soriano; targeted mutation 1, Karolinska Institutet
• MGI ID: MGI:6726261
• Synonyms: R26Axin1IL, R26-Axin1-IRES2-LacZ
• Gene: Gt(ROSA)26Sor Location: Chr6:113044389-113054205 bp, - strand Genetic Position: Chr6, 52.73 cM
• Alliance: Gt(ROSA)26Sor^{tm1(CAG-Axin1,-lacZ)Kini} page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:306371
• Parent Cell Line: v6.5 (ES Cell)
• Strain of Origin: (C57BL/6 x 129S4/SvJae)F1

Mutation description

• Allele Type: Targeted (Conditional ready, Inserted expressed sequence, Reporter)
• Mutation: Insertion
• Mutation details: The targeting construct inserted into the locus a splice acceptor from pBigT, puromycin resistance gene, bovine growth hormone polyA sequence, CAGGS enhancer/promoter/intron/SA cassette, a floxed tpA (3 SV40 polyA sequences from pBigT), Axin1 with a Myc epitope tag, cassette containing IRES2-LacZ preceded by a nuclear localization signal and finally the pCAGGS polyA sequence. (J:306371)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Gt(ROSA)26Sor Mutation: 1095 strains or lines available

References

• Original: J:306371 Jensen LD, et al., Disruption of the Extracellular Matrix Progressively Impairs Central Nervous System Vascular Maturation Downstream of beta-Catenin Signaling. Arterioscler Thromb Vasc Biol. 2019 Jul;39(7):1432-1447
• All: 1 reference(s)