Gt(ROSA)26Sor^{tm1(Nrp1)Daav}
Targeted Allele Detail

Summary

• Symbol: Gt(ROSA)26Sor^{tm1(Nrp1)Daav}
• Name: gene trap ROSA 26, Philippe Soriano; targeted mutation 1, Dario AA Vignali
• MGI ID: MGI:6726259
• Synonyms: Rosa26^{LSL.mAmetrine.2A.Nrp1}
• Gene: Gt(ROSA)26Sor Location: Chr6:113044389-113054205 bp, - strand Genetic Position: Chr6, 52.73 cM
• Alliance: Gt(ROSA)26Sor^{tm1(Nrp1)Daav} page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:299786
• Parent Cell Line: JM8A3.N1 (ES Cell)
• Strain of Origin: C57BL/6N-A^tm1Brd

Mutation description

• Allele Type: Targeted (Conditional ready, Inserted expressed sequence, Reporter)
• Mutation: Insertion
• Mutation details: The construct consisting of mAmetrine-2A-Neuropilin-1 was inserted in the ATG start codon within the Rosa26 locus downstream of the lox-stop-lox cassette. Ametrine is a long stokes shift (excitation at 406 nanometers and emission at 526 nanometers) yellow fluorescent protein derived from Aequorea victoria. The linearized targeting construct was electroporated into JM8A3.N1 embryonic stem. (J:299786)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Gt(ROSA)26Sor Mutation: 1060 strains or lines available

References

• Original: J:299786 Liu C, et al., Neuropilin-1 is a T cell memory checkpoint limiting long-term antitumor immunity. Nat Immunol. 2020 Sep;21(9):1010-1021
• All: 1 reference(s)