Calca^tm3.1Rpa
Targeted Allele Detail

Summary

• Symbol: Calca^tm3.1Rpa
• Name: calcitonin/calcitonin-related polypeptide, alpha; targeted mutation 3.1, Richard D Palmiter
• MGI ID: MGI:6726096
• Synonyms: Calca^tdT, Calca^tdTomato
• Gene: Calca Location: Chr7:114230713-114235592 bp, - strand Genetic Position: Chr7, 59.99 cM
• Alliance: Calca^tm3.1Rpa page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:301067
• Parent Cell Line: G4 (ES Cell)
• Strain of Origin: (129S6/SvEvTac x C57BL/6NCrl)F1

Mutation description

• Allele Type: Targeted (Reporter)
• Mutation: Insertion
• Mutation details: The targeting construct inserted the tdTomato openreading frame into the Calca locus between just 5 of the initiation codon in exon 2 and the noncoding exon 6. An frt-flanked Sv-Neo gene was also included for positive selection. After homologous recombination in ES cells, resulting chimeras were bred with FLPase mice to remove the Sv-Neo gene. (J:301067)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Calca Mutation: 23 strains or lines available

References

• Original: J:301067 Jarvie BC, et al., Satb2 neurons in the parabrachial nucleus mediate taste perception. Nat Commun. 2021 Jan 11;12(1):224
• All: 3 reference(s)