Il1rl1^tm1.1Ayr
Targeted Allele Detail

Summary

• Symbol: Il1rl1^tm1.1Ayr
• Name: interleukin 1 receptor-like 1; targeted mutation 1.1, Alexander Y Rudensky
• MGI ID: MGI:6725823
• Synonyms: Il1rl1^fl
• Gene: Il1rl1 Location: Chr1:40468730-40504575 bp, + strand Genetic Position: Chr1, 19.19 cM
• Alliance: Il1rl1^tm1.1Ayr page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:307782
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: C57BL/6

Mutation description

• Allele Type: Targeted (Conditional ready)
• Mutation: Insertion
• Mutation details: A loxP site and FRT flanked neo cassette were inserted upstream of exon 3 and a loxP site was inserted downstream of exon 3 via homologous recombination. Flp mediated recombination removed the neo cassette leaving exon 3 floxed. (J:307782)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Il1rl1 Mutation: 59 strains or lines available

References

• Original: J:307782 Hemmers S, et al., T reg cell-intrinsic requirements for ST2 signaling in health and neuroinflammation. J Exp Med. 2021 Feb 1;218(2)
• All: 4 reference(s)