Kmt2d^tm1.1Mgyl
Targeted Allele Detail

Summary

• Symbol: Kmt2d^tm1.1Mgyl
• Name: lysine (K)-specific methyltransferase 2D; targeted mutation 1.1, Min Gyu Lee
• MGI ID: MGI:6725819
• Synonyms: Kmt2d^fl, Mll4^f, Mll4^flox
• Gene: Kmt2d Location: Chr15:98729550-98769085 bp, - strand
• Alliance: Kmt2d^tm1.1Mgyl page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:263340
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: Exons 16-19 (the high-mobility group domain) were flanked by loxP sites. An frt-flanked neomycin resistance gene was inserted upstream of exon 16 after the first loxP site. Flp-mediated recombination removed the selection cassette leaving exons 16-19 floxed. (J:263340)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Kmt2d Mutation: 169 strains or lines available

References

• Original: J:263340 Dhar SS, et al., MLL4 Is Required to Maintain Broad H3K4me3 Peaks and Super-Enhancers at Tumor Suppressor Genes. Mol Cell. 2018 Jun 7;70(5):825-841.e6
• All: 5 reference(s)