Hgs^tm1.1Xya
Targeted Allele Detail

Summary

• Symbol: Hgs^tm1.1Xya
• Name: HGF-regulated tyrosine kinase substrate; targeted mutation 1.1, Xiao Yang
• MGI ID: MGI:6725814
• Synonyms: Hgs^fl
• Gene: Hgs Location: Chr11:120358461-120374805 bp, + strand Genetic Position: Chr11, 84.16 cM
• Alliance: Hgs^tm1.1Xya page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:288182
• Parent Cell Line: TC1/TC-1 (ES Cell)
• Strain of Origin: 129S6/SvEvTac

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: Exon 5 was flanked by loxP sites. An FRT-flanked neomycin resistance cassette was inserted 1128 bp upstream of exon 5. Flp-mediated recombination removed the selection cassette, leaving exon 5 floxed. (J:288182)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Hgs Mutation: 38 strains or lines available

References

• Original: J:288182 Chen J, et al., Smooth Muscle Hgs Deficiency Leads to Impaired Esophageal Motility. Int J Biol Sci. 2015;11(7):794-802
• All: 3 reference(s)