Rnf43^tm1.1Npa
Targeted Allele Detail

Summary

• Symbol: Rnf43^tm1.1Npa
• Name: ring finger protein 43; targeted mutation 1.1, Novartis Pharma AG
• MGI ID: MGI:6724095
• Synonyms: Rnf43lox
• Gene: Rnf43 Location: Chr11:87553913-87626365 bp, + strand Genetic Position: Chr11, 52.17 cM
• Alliance: Rnf43^tm1.1Npa page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:236636
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: C57BL/6

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: A loxP site was inserted into intron 5 and a second loxP site into intron 7. The loxP sites are approximately 1.3 kb apart and flank RING domain coding exons 6-7. The FRT site flanked neomycin resistance gene cassette that was also inserted, was removed through subsequent flp-mediated recombination. (J:236636)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Rnf43 Mutation: 37 strains or lines available

References

• Original: J:236636 Planas-Paz L, et al., The RSPO-LGR4/5-ZNRF3/RNF43 module controls liver zonation and size. Nat Cell Biol. 2016 May;18(5):467-79
• All: 1 reference(s)