Gt(ROSA)26Sor^{tm10(tetO-Znrf3,CAG-rtTA)Npa}
Targeted Allele Detail

Summary

• Symbol: Gt(ROSA)26Sor^{tm10(tetO-Znrf3,CAG-rtTA)Npa}
• Name: gene trap ROSA 26, Philippe Soriano; targeted mutation 10, Novartis Pharma AG
• MGI ID: MGI:6724075
• Synonyms: Znrf3ECD
• Gene: Gt(ROSA)26Sor Location: Chr6:113044389-113054205 bp, - strand Genetic Position: Chr6, 52.73 cM
• Alliance: Gt(ROSA)26Sor^{tm10(tetO-Znrf3,CAG-rtTA)Npa} page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:236636
• Parent Cell Line: AK7 (ES Cell)
• Strain of Origin: 129S4/SvJaeSor

Mutation description

• Allele Type: Targeted (Inducible, Inserted expressed sequence)
• Inducer: doxycycline/tetracycline
• Mutation: Insertion
• Mutation details: The tetO tetracycline responsive element followed by cDNA sequence coding for the zinc and ring finger 3 extracellular domain were inserted into exon 1 of the locus. The CAG promoter followed by the rtTA16 transactivator cDNA was inserted into intron 1 in the reverse transcriptional direction. This allele expresses the Znrf3 sequence in the presence of doxycycline. (J:236636)
• Inheritance: Not Specified

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Gt(ROSA)26Sor Mutation: 1061 strains or lines available

References

• Original: J:236636 Planas-Paz L, et al., The RSPO-LGR4/5-ZNRF3/RNF43 module controls liver zonation and size. Nat Cell Biol. 2016 May;18(5):467-79
• All: 1 reference(s)