Lgr5^tm2.1Npa
Targeted Allele Detail

Summary

• Symbol: Lgr5^tm2.1Npa
• Name: leucine rich repeat containing G protein coupled receptor 5; targeted mutation 2.1, Novartis Pharma AG
• MGI ID: MGI:6724063
• Synonyms: Lgr5lox, LGR5tm1Npa
• Gene: Lgr5 Location: Chr10:115286219-115423685 bp, - strand Genetic Position: Chr10, 63.51 cM
• Alliance: Lgr5^tm2.1Npa page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:236636
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: C57BL/6

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: A loxP site was inserted upstream of exon 1 and a second loxP site into intron 1. The loxP sites are approximately 1.6 kb apart and flank the start codon-containing first exon. The FRT site flanked neomycin resistance gene cassette that was also inserted, was removed through subsequent flp-mediated recombination. (J:236636)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Lgr5 Mutation: 58 strains or lines available

References

• Original: J:236636 Planas-Paz L, et al., The RSPO-LGR4/5-ZNRF3/RNF43 module controls liver zonation and size. Nat Cell Biol. 2016 May;18(5):467-79
• All: 2 reference(s)