Tg(Myh6-Akt1*)6445Gcon
Transgene Detail

Summary

• Symbol: Tg(Myh6-Akt1*)6445Gcon
• Name: transgene insertion 6445, Gianluigi Condorelli
• MGI ID: MGI:6721418
• Synonyms: alphaMHC-Akt^tg, CAkt^tg, E40K-Akt
• Transgene: Tg(Myh6-Akt1*)6445Gcon Location: unknown
• Alliance: Tg(Myh6-Akt1*)6445Gcon page

Transgene origin

• Strain of Origin: Not Applicable

Transgene description

• Transgene Type: Transgenic (Constitutively active, Inserted expressed sequence)
• Mutation: Insertion
• Tg(Myh6-Akt1*)6445Gcon expresses 1 gene
  Transgene expresses:
  

  Organism	Expressed Gene	Note
  mouse	Akt1 (MGI:87986)	mouse promoter and cDNA

• Mutation details: This transgene insert contains the following elements: mouse cardiac muscle myosin heavy polypeptide 6 alpha promoter sequence to drive the heart-specific expression of a constitutively active mutated form of the mouse thymoma viral proto-oncogene 1 cDNA where codon 40 was changed from glutamic acid to lysine (p.E40K) through a G-to-A point mutation (c.118G>A), and SV40 intron and poly(A) signal sequences. (J:258598)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available

References

• Original: J:258598 Condorelli G, et al., Akt induces enhanced myocardial contractility and cell size in vivo in transgenic mice. Proc Natl Acad Sci U S A. 2002 Sep 17;99(19):12333-8
• All: 6 reference(s)