Plxnb3
Targeted Allele Detail

Summary

• Symbol: Plxnb3
• Name: plexin B3; targeted mutation 1, Stefan Offermanns
• MGI ID: MGI:6721102
• Gene: Plxnb3 Location: ChrX:72800696-72816120 bp, + strand Genetic Position: ChrX, 37.4 cM
• Alliance: Plxnb3 page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:307447
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: The mutation is a deletion of exons 317 and part of exon 18 by replacing them with a sequence encoding for enhanced green fluorescent protein (EGFP) followed by a human growth hormone polyadenylation sequence and a neomycin resistance cassette. EGFP expression was not detected in the mutant animals. Endogenous Plexin-B3 mRNA and Plexin-B3 protein expression was undetectable via RT-PCR and Western blot analysis respectively, in brains of 4-week-old homozygous mice. (J:307447)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Plxnb3 Mutation: 16 strains or lines available

References

• Original: J:307447 Worzfeld T, et al., Mice lacking Plexin-B3 display normal CNS morphology and behaviour. Mol Cell Neurosci. 2009 Dec;42(4):372-81
• All: 1 reference(s)