Plxnb3
Targeted Allele Detail
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| Symbol: |
Plxnb3 |
| Name: |
plexin B3; targeted mutation 1, Stefan Offermanns |
| MGI ID: |
MGI:6721102 |
| Gene: |
Plxnb3 Location: ChrX:72800696-72816120 bp, + strand Genetic Position: ChrX, 37.4 cM
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| Alliance: |
Plxnb3 page
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| Germline Transmission: |
Earliest citation of germline transmission:
J:307447
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| Parent Cell Line: |
Not Specified (ES Cell)
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| Strain of Origin: |
Not Specified
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| Allele Type: |
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Targeted (Null/knockout) |
| Mutations: |
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Insertion, Intragenic deletion
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Mutation details: The mutation is a deletion of exons 317 and part of exon 18 by replacing them with a sequence encoding for enhanced green fluorescent protein (EGFP) followed by a human growth hormone polyadenylation sequence and a neomycin resistance cassette. EGFP expression was not detected in the mutant animals. Endogenous Plexin-B3 mRNA and Plexin-B3 protein expression was undetectable via RT-PCR and Western blot analysis respectively, in brains of 4-week-old homozygous mice.
(J:307447)
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| Mouse strains and cell lines
available from the International Mouse Strain Resource
(IMSR) |
| Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available
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| Carrying any Plxnb3 Mutation: |
15 strains or lines available
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| Original: |
J:307447 Worzfeld T, et al., Mice lacking Plexin-B3 display normal CNS morphology and behaviour. Mol Cell Neurosci. 2009 Dec;42(4):372-81 |
| All: |
1 reference(s) |
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Analysis Tools
