Adamts5^em1Mlkn
Endonuclease-mediated Allele Detail

Summary

• Symbol: Adamts5^em1Mlkn
• Name: ADAM metallopeptidase with thrombospondin type 1 motif 5; endonuclease-mediated mutation 1, Mark L Kahn
• MGI ID: MGI:6720274
• Synonyms: Adamts5^fl
• Gene: Adamts5 Location: Chr16:85655045-85698013 bp, - strand Genetic Position: Chr16, 48.34 cM
• Alliance: Adamts5^em1Mlkn page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:298707
• Parent Cell Line: v6.5 (ES Cell)
• Strain of Origin: (C57BL/6 x 129S4/SvJae)F1

Mutation description

• Allele Type: Endonuclease-mediated (Conditional ready)
• Mutation: Insertion
• Mutation details: A targeting construct comprised of 1.5 kb flanking homology arms, floxed exon 3, and a flippase recombination targetflanked neomycin resistance cassette replaced endogenous Adamts5 sequences by CRISPR/Cas9-mediated homologous recombination in ES cells. (J:298707)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Adamts5 Mutation: 56 strains or lines available

References

• Original: J:298707 Hong CC, et al., Cerebral cavernous malformations are driven by ADAMTS5 proteolysis of versican. J Exp Med. 2020 Oct 5;217(10)
• All: 1 reference(s)