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Endonuclease-mediated Allele Detail
Symbol: Adam17em1Bbl
Name: a disintegrin and metallopeptidase domain 17; endonuclease-mediated mutation1, Carl Blobel
MGI ID: MGI:6719382
Synonyms: Adam17deltacyto
Gene: Adam17  Location: Chr12:21373510-21423633 bp, - strand  Genetic Position: Chr12, 8.3 cM
Strain of Origin:  B6(Cg)-Tyrc-2J/J
Allele Type:    Endonuclease-mediated (Epitope tag, Hypomorph)
Mutation:    Insertion
Mutation detailsCRISPR/cas9 endonuclease-mediated genome editing is used to insert a hemaglutinin (HA) tag and stop codon into exon 18 (the cytoplasmic domain). Western blot analysis confirms that the mutation results in decreased protein levels in brain, heart, lung, liver and spleen. (J:306272)
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Adam17 Mutation:  43 strains or lines available
Original:  J:306272 Lora J, et al., Targeted truncation of the ADAM17 cytoplasmic domain in mice results in protein destabilization and a hypomorphic phenotype. J Biol Chem. 2021 May 3;:100733
All:  1 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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MGI 6.17
The Jackson Laboratory