Gt(ROSA)26Sor^{tm1(Cd74/GP61-80)Jher}
Targeted Allele Detail

Summary

• Symbol: Gt(ROSA)26Sor^{tm1(Cd74/GP61-80)Jher}
• Name: gene trap ROSA 26, Philippe Soriano; targeted mutation 1, Johannes Herkel
• MGI ID: MGI:6719204
• Synonyms: iGP
• Gene: Gt(ROSA)26Sor Location: Chr6:113044389-113054205 bp, - strand Genetic Position: Chr6, 52.73 cM
• Alliance: Gt(ROSA)26Sor^{tm1(Cd74/GP61-80)Jher} page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:306965
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Conditional ready, Inserted expressed sequence)
• Mutation: Insertion
• Mutation details: A floxed STOP cassette and a mutated invariant chain molecule Cd74 cDNA in which the sequence encoding the CLIP domain was replaced with the immunodominant GP61-80 peptide sequence of LCMV were inserted into the locus. Expression of the fusion product is only achieved following cre mediated recombination. (J:306965)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Gt(ROSA)26Sor Mutation: 1084 strains or lines available

References

• Original: J:306965 Preti M, et al., Failure of thymic deletion and instability of autoreactive Tregs drive autoimmunity in immune-privileged liver. JCI Insight. 2021 Mar 22;6(6)
• All: 1 reference(s)