Pomc^tm2.1Lowl
Targeted Allele Detail

Summary

• Symbol: Pomc^tm2.1Lowl
• Name: pro-opiomelanocortin-alpha; targeted mutation 2.1, Bradford B Lowell
• MGI ID: MGI:6718624
• Synonyms: Pomc^lox
• Gene: Pomc Location: Chr12:4004951-4010642 bp, + strand Genetic Position: Chr12, 1.99 cM
• Alliance: Pomc^tm2.1Lowl page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:303221
• Parent Cell Line: W4 (ES Cell)
• Strain of Origin: 129S6/SvEvTac

Mutation description

• Allele Type: Targeted (Conditional ready)
• Mutation: Insertion
• Mutation details: Mice with lox sites flanking exon III of the Pomc gene were generated using gene targeting in ES cells. The founders were bred to female mice bearing a germline-expressing Flpe recombinase transgene to obtain germ-line transmission of the floxed Pomc allele and to remove the frt-kanamycin-frt cassette. (J:303221)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Pomc Mutation: 20 strains or lines available

References

• Original: J:303221 Fenselau H, et al., A rapidly acting glutamatergic ARC-->PVH satiety circuit postsynaptically regulated by alpha-MSH. Nat Neurosci. 2017 Jan;20(1):42-51
• All: 1 reference(s)