Gt(ROSA)26Sor^{tm1(CAG-VPS35*D620N)Lze}
Targeted Allele Detail

Summary

• Symbol: Gt(ROSA)26Sor^{tm1(CAG-VPS35*D620N)Lze}
• Name: gene trap ROSA 26, Philippe Soriano; targeted mutation 1, Li Zeng
• MGI ID: MGI:6718577
• Gene: Gt(ROSA)26Sor Location: Chr6:113044389-113054205 bp, - strand Genetic Position: Chr6, 52.73 cM
• Alliance: Gt(ROSA)26Sor^{tm1(CAG-VPS35*D620N)Lze} page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:306945
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: C57BL/6J

Mutation description

• Allele Type: Targeted (Conditional ready, Epitope tag, Humanized sequence, Inserted expressed sequence)
• Mutation: Insertion
• Mutation details: A targeting vector consisting of a CAG promoter, loxP-stop-loxP (LSL) cassette and HA-tagged human VPS35 containing an aspartate to asparagine substitution at amino acid 620 (D620N) was inserted into the locus. The D620N mutation has been identified as a pathogenic mutation for late-onset autosomal dominant Parkinson's disease. (J:306945)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Gt(ROSA)26Sor Mutation: 1061 strains or lines available

References

• Original: J:306945 Jiang M, et al., Impaired neurogenesis in the hippocampus of an adult VPS35 mutant mouse model of Parkinson's disease through interaction with APP. Neurobiol Dis. 2021 Jun;153:105313
• All: 1 reference(s)