Asb2^tm1.2Lutz
Targeted Allele Detail

Summary

• Symbol: Asb2^tm1.2Lutz
• Name: ankyrin repeat and SOCS box-containing 2; targeted mutation 1.2, Pierre Lutz
• MGI ID: MGI:6718523
• Gene: Asb2 Location: Chr12:103287401-103322260 bp, - strand Genetic Position: Chr12, 52.9 cM
• Alliance: Asb2^tm1.2Lutz page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:306706
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: 129S2/SvPas

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: An FRT- and loxP-flanked neomycin resistance cassette was inserted usptream of exon 2. An additional loxP site was inserted downstream of exon 4. Flp-mediated recombination removed the neomycin resistance cassette and left exons 2 through 4 floxed. Cre-mediated recombination removed exons 2 through 4. (J:306706)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Asb2 Mutation: 27 strains or lines available

References

• Original: J:306706 Metais A, et al., Asb2alpha-Filamin A Axis Is Essential for Actin Cytoskeleton Remodeling During Heart Development. Circ Res. 2018 Mar 16;122(6):e34-e48
• All: 1 reference(s)