Dhh^tm1.2Ics
Targeted Allele Detail

Summary

• Symbol: Dhh^tm1.2Ics
• Name: desert hedgehog; targeted mutation 1.2, Mouse Clinical Institute
• MGI ID: MGI:6718482
• Gene: Dhh Location: Chr15:98789033-98796421 bp, - strand Genetic Position: Chr15, 55.05 cM
• Alliance: Dhh^tm1.2Ics page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:292199
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: The targeting construct inserted an FRT-flanked beta-geo cassette with a 3' loxP site upstream of exon 2. An additional loxP site was inserted downstream of exon 3. Flp-mediated recombination removed the reporter/selection cassette and left exon 2 and 3 floxed. Cre-mediated recombination removed exons 2 and 3. (J:292199)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Dhh Mutation: 20 strains or lines available

References

• Original: J:292199 Caradu C, et al., Restoring Endothelial Function by Targeting Desert Hedgehog Downstream of Klf2 Improves Critical Limb Ischemia in Adults. Circ Res. 2018 Oct 12;123(9):1053-1065
• All: 2 reference(s)