Trp53^tm1Gpz
Targeted Allele Detail

Summary

• Symbol: Trp53^tm1Gpz
• Name: transformation related protein 53; targeted mutation 1, Gerard P Zambetti
• MGI ID: MGI:6718303
• Gene: Trp53 Location: Chr11:69471185-69482699 bp, + strand Genetic Position: Chr11, 42.83 cM, cytoband B2-C
• Alliance: Trp53^tm1Gpz page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:305549
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: 129X1/SvJ

Mutation description

• Allele Type: Targeted (Humanized sequence)
• Mutations: Insertion, Single point mutation
• Mutation details: A G to C mutation resulting in an arginine to histidine substitution at amino acid 334 (R334H) was introduced in exon 10 and a loxP-flanked cassette containing neomycin resistance and thymidine kinase genes was inserted in intron 9. This is a mutation associated with variable tumor susceptibility in humans. (J:305549)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Trp53 Mutation: 237 strains or lines available

References

• Original: J:305549 Jeffers JR, et al., The Common Germline TP53-R337H Mutation is Hypomorphic and Confers Incomplete Penetrance and Late Tumor Onset in a Mouse Model. Cancer Res. 2021 Feb 26
• All: 1 reference(s)