Il11^tm1Hna
Targeted Allele Detail

Summary

• Symbol: Il11^tm1Hna
• Name: interleukin 11; targeted mutation 1, Hiroyasu Nakano
• MGI ID: MGI:6716018
• Synonyms: Il11-Egfp
• Gene: Il11 Location: Chr7:4775372-4785858 bp, - strand Genetic Position: Chr7, 2.76 cM
• Alliance: Il11^tm1Hna page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:306086
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: C57BL/6

Mutation description

• Allele Type: Targeted (Reporter)
• Mutation: Insertion
• Mutation details: An EGFP gene with poly(A) signal sequence was inserted between the 2nd and 3rd nucleotide of exon 2 of the Il11 gene on BAC clone RP23-285B12 to create an Il11 promoter-driven Il11/EGFP fusion gene coding for the first three Il11 amino-acids followed by the EGFP peptide. The modified BAC was injected into oocytes together with sperm through Intracytoplasmic sperm injection (ICSI). (J:306086)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Il11 Mutation: 21 strains or lines available

References

• Original: J:306086 Nishina T, et al., Interleukin-11-expressing fibroblasts have a unique gene signature correlated with poor prognosis of colorectal cancer. Nat Commun. 2021 Apr 16;12(1):2281
• All: 1 reference(s)