Klf2^tm1.1Khog
Targeted Allele Detail

Summary

• Symbol: Klf2^tm1.1Khog
• Name: Kruppel-like transcription factor 2 (lung); targeted mutation 1.1, Kristin A Hogquist
• MGI ID: MGI:6715556
• Synonyms: Klf2^GFP
• Gene: Klf2 Location: Chr8:73072906-73075498 bp, + strand Genetic Position: Chr8, 34.99 cM, cytoband C1
• Alliance: Klf2^tm1.1Khog page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:101977
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: C57BL/6

Mutation description

• Allele Type: Targeted (Null/knockout, Reporter)
• Mutation: Insertion
• Mutation details: The targeting vector is designed to insert an enhanced green fluorescent protein (EGFP) sequence into the translational start site in exon 1. A loxP-flanked neomycin resistance (neo) cassette was inserted downstream of exon 2. Cre-mediated recombination removed the floxed neo cassette. (J:151604)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Klf2 Mutation: 13 strains or lines available

Notes

The version of this allele that contains the neomycin selection cassette, Klf2^tm1Khog, has been analyzed.

References

• Original: J:151604 Weinreich MA, et al., KLF2 transcription-factor deficiency in T cells results in unrestrained cytokine production and upregulation of bystander chemokine receptors. Immunity. 2009 Jul 17;31(1):122-30
• All: 8 reference(s)