N4bp1^m2Btlr
Chemically induced Allele Detail

Summary

• Symbol: N4bp1^m2Btlr
• Name: NEDD4 binding protein 1; mutation 2, Bruce Beutler
• MGI ID: MGI:6714217
• Synonyms: N4bp1^stash
• Gene: N4bp1 Location: Chr8:87567764-87612489 bp, - strand Genetic Position: Chr8, 42.1 cM
• Alliance: N4bp1^m2Btlr page

Mutation origin

• Strain of Origin: C57BL/6J
• Project Collection: Beutler Mutagenetix

Mutation description

• Allele Type: Chemically induced (ENU) (Not Specified)
• Mutation: Single point mutation
• Mutation details: ENU induced a point mutation that results in the amino acid substitution of lysine at position 66 (K66). (J:304890)
• Inheritance: Recessive

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any N4bp1 Mutation: 46 strains or lines available

References

• Original: J:304890 Shi H, et al., N4BP1 negatively regulates NF-kappaB by binding and inhibiting NEMO oligomerization. Nat Commun. 2021 Mar 2;12(1):1379
• All: 1 reference(s)