Flt4^tm2.2Ali
Targeted Allele Detail

Summary

• Symbol: Flt4^tm2.2Ali
• Name: FMS-like tyrosine kinase 4; targeted mutation 2.2, Kari Alitalo
• MGI ID: MGI:6714173
• Gene: Flt4 Location: Chr11:49500506-49543566 bp, + strand Genetic Position: Chr11, 29.69 cM, cytoband A5-B1
• Alliance: Flt4^tm2.2Ali page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:305417
• Parent Cell Line: R1 (ES Cell)
• Strain of Origin: (129X1/SvJ x 129S1/Sv)F1-Kitl⁺

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A loxP site was inserted upstream of the translation initiation codon and a floxed, frt-flanked neo cassette was inserted downstream of exon 1. The frt flanked neo cassette was then removed by germ-line FLPe-mediated recombination. Cre-mediated recombination removed exon 1. (J:305417)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Flt4 Mutation: 77 strains or lines available

References

• Original: J:305417 Martucciello S, et al., A dual role for Tbx1 in cardiac lymphangiogenesis through genetic interaction with Vegfr3. FASEB J. 2020 Nov;34(11):15062-15079
• All: 1 reference(s)