Usp20^em1Dalin
Endonuclease-mediated Allele Detail

Summary

• Symbol: Usp20^em1Dalin
• Name: ubiquitin specific peptidase 20; endonuclease-mediated mutation 1, Dandan Lin
• MGI ID: MGI:6713512
• Gene: Usp20 Location: Chr2:30872291-30912667 bp, + strand Genetic Position: Chr2, 21.77 cM, cytoband B
• Alliance: Usp20^em1Dalin page

Mutation origin

• Strain of Origin: Not Specified

Mutation description

• Allele Type: Endonuclease-mediated (Null/knockout)
• Mutation: Intragenic deletion
• Mutation details: CRISPR/Cas9 technology using sgRNAs 5'-GACCTTCGCCAGTGTACCTGTGG-3' and 5'-GTCCTACTGTGCAGCACTCGTGG-3' deleted exons 4 to 9 (7682 bp deletion) resulting in early translational termination. (J:274572)

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Usp20 Mutation: 49 strains or lines available

References

• Original: J:274572 Zhang MX, et al., USP20 Promotes Cellular Antiviral Responses via Deconjugating K48-Linked Ubiquitination of MITA. J Immunol. 2019 Apr 15;202(8):2397-2406
• All: 1 reference(s)