Hspa12b^tm1.1Chli
Targeted Allele Detail

Summary

• Symbol: Hspa12b^tm1.1Chli
• Name: heat shock protein 12B; targeted mutation 1.1, Chuanfu Li
• MGI ID: MGI:6712704
• Gene: Hspa12b Location: Chr2:130969332-130987905 bp, + strand Genetic Position: Chr2, 63.27 cM, cytoband F3
• Alliance: Hspa12b^tm1.1Chli page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:303578
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Conditional ready)
• Mutation: Insertion
• Mutation details: A loxP site was inserted upstream of exon 2 and a loxP-flanked PGK-neomycin selection cassette was inserted downstream of exon 2. Cre-mediated recombination removed the selection cassette, leaving exon 2 floxed. (J:303578)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Hspa12b Mutation: 7 strains or lines available

References

• Original: J:303578 Zhang X, et al., Endothelial HSPA12B Exerts Protection Against Sepsis-Induced Severe Cardiomyopathy via Suppression of Adhesion Molecule Expression by miR-126. Front Immunol. 2020;11:566
• All: 4 reference(s)