Gt(ROSA)26Sor^em1(TAg)Sac
Endonuclease-mediated Allele Detail

Summary

• Symbol: Gt(ROSA)26Sor^em1(TAg)Sac
• Name: gene trap ROSA 26, Philippe Soriano; endonuclease-mediated mutation 1, Sally Camper
• MGI ID: MGI:6711970
• Synonyms: Rosa26^LSL-SV40-GFP
• Gene: Gt(ROSA)26Sor Location: Chr6:113044389-113054205 bp, - strand Genetic Position: Chr6, 52.73 cM
• Alliance: Gt(ROSA)26Sor^em1(TAg)Sac page

Mutation origin

• Strain of Origin: (C57BL/6 x SJL)F1

Mutation description

• Allele Type: Endonuclease-mediated (Conditional ready, Inserted expressed sequence, Reporter)
• Mutation: Insertion
• Mutation details: CRISPR/cas9 genome editing is used to insert a floxed STOP cassette (including a neomycin resistance cassette), an SV40 T antigen coding region, an internal ribosome entry site (IRES), and an enhanced green fluorescent protein (EGFP) sequence into the endogenous Gt(ROSA)26Sor locus. (J:305948)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Gt(ROSA)26Sor Mutation: 1084 strains or lines available

References

• Original: J:305948 Daly AZ, et al., Pituitary tumors and immortalized cell lines generated by cre-inducible expression of SV40 T antigen. Endocrinology. 2021 Apr 10
• All: 1 reference(s)