Casq2^tm1.1Kpfe
Targeted Allele Detail

Summary

• Symbol: Casq2^tm1.1Kpfe
• Name: calsequestrin 2; targeted mutation 1.1, Karl Pfeifer
• MGI ID: MGI:6711692
• Synonyms: Casq2^floxed
• Gene: Casq2 Location: Chr3:101993731-102053830 bp, + strand Genetic Position: Chr3, 44.3 cM, cytoband F3
• Alliance: Casq2^tm1.1Kpfe page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:114621
• Parent Cell Line: R1 (ES Cell)
• Strain of Origin: (129X1/SvJ x 129S1/Sv)F1-Kitl⁺

Mutation description

• Allele Type: Targeted (Conditional ready)
• Mutation: Insertion
• Mutation details: The targeting vector is designed to insert loxP sites flanking the promoter and first exon (at positions -561 bp and at +538 bp relative to the major transcriptional start site). An FRT-flanked neomycin resistance (neo) cassette was inserted in intron 1, between exons 1 and 2. Flp-mediated recombination removed the FRT-flanked neo cassette. (J:114621)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Casq2 Mutation: 34 strains or lines available

References

• Original: J:114621 Knollmann BC, et al., Casq2 deletion causes sarcoplasmic reticulum volume increase, premature Ca2+ release, and catecholaminergic polymorphic ventricular tachycardia. J Clin Invest. 2006 Sep;116(9):2510-20
• All: 3 reference(s)