Prss56^tm1.1Nais
Targeted Allele Detail

Summary

• Symbol: Prss56^tm1.1Nais
• Name: serine protease 56; targeted mutation 1, K Saidas Nair
• MGI ID: MGI:6711409
• Synonyms: Prss56^F
• Gene: Prss56 Location: Chr1:87111035-87116127 bp, + strand Genetic Position: Chr1, 44.07 cM, cytoband C5
• Alliance: Prss56^tm1.1Nais page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:260109
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Conditional ready)
• Mutation: Insertion
• Mutation details: A loxP site was inserted upstream of exon 3 and an FRT flanked neo cassette and loxP site were inserted downstream of exon 4 via homologous recombination. Flp mediated recombination removed the neo cassette leaving exons 3 and 4 floxed. (J:260109)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Prss56 Mutation: 23 strains or lines available

References

• Original: J:260109 Paylakhi S, et al., Muller glia-derived PRSS56 is required to sustain ocular axial growth and prevent refractive error. PLoS Genet. 2018 Mar;14(3):e1007244
• All: 3 reference(s)