Dyrk2^tm1.1Kyos
Targeted Allele Detail

Summary

• Symbol: Dyrk2^tm1.1Kyos
• Name: dual-specificity tyrosine phosphorylation regulated kinase 2; targeted mutation 1.1, Kiyotsugu Yoshida
• MGI ID: MGI:6711272
• Synonyms: Dyrk2^-, Dyrk2^tm1b
• Gene: Dyrk2 Location: Chr10:118691508-118706114 bp, - strand Genetic Position: Chr10, 66.75 cM
• Alliance: Dyrk2^tm1.1Kyos page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:298652
• Parent Cell Line: JM8A3.N1 (ES Cell)
• Strain of Origin: C57BL/6N-A^tm1Brd

Mutation description

• Allele Type: Targeted (Null/knockout, Reporter)
• Mutations: Insertion, Intragenic deletion
• Mutation details: KOMP targeting vectors PG00105_X_1_G09 and PG00105_X_1_E04 were used to create a knockout-first conditional-ready reporter allele. The vector places an FRT site, splice acceptor site, IRES, lacZ cassette, loxP site, neomycin resistance gene cassette, second FRT site and second loxP site into intron 2 and a third loxP site into intron 3. Exon 3 and the neo cassette were deleted through subsequent cre-mediated recombination. (J:298652)

Expression

In Structures Affected by this Mutation:

8 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Dyrk2 Mutation: 30 strains or lines available

References

• Original: J:298652 Yoshida S, et al., The novel ciliogenesis regulator DYRK2 governs Hedgehog signaling during mouse embryogenesis. Elife. 2020 Aug 6;9:e57381
• All: 1 reference(s)