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Tg(CAG-ACE2)GT5-027Cyt
Transgene Detail
Nomenclature
Symbol: Tg(CAG-ACE2)GT5-027Cyt
Name: transgene insertion GT5-027, Ching-Yen Tsai
MGI ID: MGI:6711183
Synonyms: CAG-hACE2
Transgene: Tg(CAG-ACE2)GT5-027Cyt  Location: unknown  
Transgene
origin
Strain of Origin:  C57BL/6J
Transgene
description
Transgene Type:    Transgenic (Epitope tag, Humanized sequence, Inserted expressed sequence)
Mutation:    Insertion
 
Tg(CAG-ACE2)GT5-027Cyt expresses 1 gene
 
Mutation detailsThe transgenic construct contains 2 copies of a chicken HS4 insulator sequence, a CMV enhancer/chicken beta-actin (CAG) promoter, full length a hemaglutatin (HA) tagged human angiotensin I converting enzyme (peptidyl-dipeptidase A) 2 (hACE2) cDNA, and 2 more copies of the chicken HS4 insulator. Founder lines GT5-027 and GT4-008 were generated. GT5-027 carries two copies of the transgene and was used in experiments. High expression levels are detected in lung, kidney and brain. (J:305559)
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
References
Original:  J:305559 Tsai C-Y, et al., Sex-biased response to and brain cell infection by SARS-CoV-2 in a highly susceptible human ACE2 transgenic model. bioRxiv. 2021;
All:  2 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
10/05/2021
MGI 6.17
The Jackson Laboratory