Ripk3^tm1.2Fkmc
Targeted Allele Detail

Summary

• Symbol: Ripk3^tm1.2Fkmc
• Name: receptor-interacting serine-threonine kinase 3; targeted mutation 1.2, Francis Chan
• MGI ID: MGI:6711171
• Synonyms: Ripk3^deltaR
• Gene: Ripk3 Location: Chr14:56022452-56026314 bp, - strand Genetic Position: Chr14, 28.19 cM, cytoband C1
• Alliance: Ripk3^tm1.2Fkmc page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:239293
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: 129/Sv

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutation: Intragenic deletion
• Mutation details: A loxP site and a FRT site flanked neomycin resistance gene cassette were inserted into intron 9. An enhanced green fluorescent protein (EGFP) sequence, followed by a second loxP site, was inserted at the end of the coding region. Flp-mediated recombination removed the neo cassette and Cre-mediated recombination removed exon 10 and flanking intron sequences. (J:239293)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Ripk3 Mutation: 34 strains or lines available

References

• Original: J:239293 Moriwaki K, et al., Distinct Kinase-Independent Role of RIPK3 in CD11c+ Mononuclear Phagocytes in Cytokine-Induced Tissue Repair. Cell Rep. 2017 Mar 07;18(10):2441-2451
• All: 3 reference(s)