Cux1^em1.1Cwon
Endonuclease-mediated Allele Detail

Summary

• Symbol: Cux1^em1.1Cwon
• Name: cut-like homeobox 1; endonuclease-mediated mutation 1.1, Chi C Wong
• MGI ID: MGI:6710996
• Gene: Cux1 Location: Chr5:136276989-136596344 bp, - strand Genetic Position: Chr5, 75.96 cM
• Alliance: Cux1^em1.1Cwon page

Mutation origin

• Strain of Origin: C57BL/6N

Mutation description

• Allele Type: Endonuclease-mediated (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• CRISPR-targeting floxed exons 15 through 18. Cre-mediated recombination removed exons 15 through 18. (J:305258)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Cux1 Mutation: 112 strains or lines available

References

• Original: J:305258 Supper E, et al., Cut-like homeobox 1 (CUX1) tumor suppressor gene haploinsufficiency induces apoptosis evasion to sustain myeloid leukemia. Nat Commun. 2021;12(1):2482
• All: 1 reference(s)