Ddr1^tm1.1Czw
Targeted Allele Detail

Summary

• Symbol: Ddr1^tm1.1Czw
• Name: discoidin domain receptor family, member 1; targeted mutation 1.1, Chau-Zen Wang
• MGI ID: MGI:6710983
• Synonyms: Ddr1^f
• Gene: Ddr1 Location: Chr17:35992459-36015513 bp, - strand Genetic Position: Chr17, 18.7 cM, cytoband C
• Alliance: Ddr1^tm1.1Czw page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:305213
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: 129

Mutation description

• Allele Type: Targeted (Conditional ready)
• Mutation: Insertion
• Mutation details: The targeting vectors harboring loxP before exons 2 and after exon 12 followed by the FRT flanked neomycin resistance cassette was electroporated into embryonic stem (ES) cells to generate a conditional allele. The chimeric mice, and the offspring were crossed with flippase transgenic mice to remove the neomycin resistance cassette. (J:305213)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Ddr1 Mutation: 35 strains or lines available

References

• Original: J:305213 Chou LY, et al., Discoidin domain receptor 1 regulates endochondral ossification through terminal differentiation of chondrocytes. FASEB J. 2020 Apr;34(4):5767-5781
• All: 1 reference(s)