Tlr3^tm1.1Lwtn
Targeted Allele Detail

Summary

• Symbol: Tlr3^tm1.1Lwtn
• Name: toll-like receptor 3; targeted mutation 1.1, J Lindsay Whitton
• MGI ID: MGI:6704903
• Gene: Tlr3 Location: Chr8:45848702-45864112 bp, - strand Genetic Position: Chr8, 25.31 cM, cytoband B2
• Alliance: Tlr3^tm1.1Lwtn page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:101977
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: C57BL/6

Mutation description

• Allele Type: Targeted (Conditional ready)
• Mutation: Insertion
• Mutation details: Targeting vector PRPGS00208_A_B10 from the KOMP Repository was used to create the allele. The construct includes an FRT site followed by a beta-galactosidase (lacZ) gene, and a polyadenylation site (SV40 polyA). This was followed by a loxP site, a neomycin resistance gene, a SV40 polyA, a second FRT site and a second loxP site inserted downstream of exon 5. A third loxP site is inserted in exon 7. Flp-mediated recombination removed the FRT-flanked neo cassette/lacZ sequences. (J:101977)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Tlr3 Mutation: 72 strains or lines available

References

• Original: J:101977 The Jackson Laboratory, Information obtained from The Jackson Laboratory, Bar Harbor, ME. Unpublished. 2005-2017
• All: 1 reference(s)