Atm^tm2.2Fwa
Targeted Allele Detail

Summary

• Symbol: Atm^tm2.2Fwa
• Name: ataxia telangiectasia mutated; targeted mutation 2.2, Frederick W Alt
• MGI ID: MGI:6696452
• Synonyms: Atm^delta
• Gene: Atm Location: Chr9:53350449-53448040 bp, - strand Genetic Position: Chr9, 29.12 cM, cytoband C-D
• Alliance: Atm^tm2.2Fwa page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:303736
• Parent Cell Line: TC1/TC-1 (ES Cell)
• Strain of Origin: 129S6/SvEvTac

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutation: Intragenic deletion
• Mutation details: Sequence encoding the core PIKK kinase domain of the protein protein product were floxed by placing a loxP site upstream of exon 57 and floxed neomycin cassette downstream of exon 58. The neomycin cassette was subsequently removed by transient infection of cre recombinase, and exons 57-58 were removed via Cre-mediated recombination in the germline. (J:303736)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Atm Mutation: 168 strains or lines available

References

• Original: J:303736 Saunders RA, et al., Elevated inflammatory responses and targeted therapeutic intervention in a preclinical mouse model of ataxia-telangiectasia lung disease. Sci Rep. 2021 Feb 19;11(1):4268
• All: 1 reference(s)