Rras^tm1.1Geno
Targeted Allele Detail

Summary

• Symbol: Rras^tm1.1Geno
• Name: RAS oncogene related; targeted mutation 1.1 Genoway
• MGI ID: MGI:6696451
• Synonyms: R-ras^-
• Gene: Rras Location: Chr7:44667385-44671071 bp, + strand Genetic Position: Chr7, 29.08 cM
• Alliance: Rras^tm1.1Geno page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:303687
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: 129S2/SvPas

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A neomycin resistance cassette flanked by FRT sequences was inserted in Intron 1, and loxP sites were inserted flanking exons 2 - 6. Exons 2-6 were deleted via Cre-mediated recombination in the germline. (J:303687, J:318848)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Rras Mutation: 22 strains or lines available

References

• Original: J:303687 Alcover-Sanchez B, et al., Absence of R-Ras1 and R-Ras2 causes mitochondrial alterations that trigger axonal degeneration in a hypomyelinating disease model. Glia. 2021 Mar;69(3):619-637
• All: 2 reference(s)