Loxhd1^tm1.1Ngt
Targeted Allele Detail

Summary

• Symbol: Loxhd1^tm1.1Ngt
• Name: lipoxygenase homology domains 1; targeted mutation 1.1, Nicolas Grillet
• MGI ID: MGI:6696448
• Synonyms: Loxhd1^T1308X
• Gene: Loxhd1 Location: Chr18:77369654-77530626 bp, + strand Genetic Position: Chr18, 52.2 cM
• Alliance: Loxhd1^tm1.1Ngt page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:304635
• Parent Cell Line: E14TG2a (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Targeted (Not Specified)
• Mutations: Insertion, Nucleotide substitutions
• Mutation details: A stop codon was inserted after the two first coding codons of exon 30 and the remaining sequence was replaced with an FRT-flanked neomycin resistance cassette. Flp-mediated recombination removed the selection cassette. (J:304635)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Loxhd1 Mutation: 108 strains or lines available

References

• Original: J:304635 Trouillet A, et al., Loxhd1 Mutations Cause Mechanotransduction Defects in Cochlear Hair Cells. J Neurosci. 2021 Apr 14;41(15):3331-3343
• All: 1 reference(s)