Nutm1^tm1Ger
Targeted Allele Detail

Summary

• Symbol: Nutm1^tm1Ger
• Name: NUT midline carcinoma, family member 1; targeted mutation 1, Matthieu Gerard
• MGI ID: MGI:6695078
• Gene: Nutm1 Location: Chr2:112078293-112089636 bp, - strand Genetic Position: Chr2, 56.97 cM
• Alliance: Nutm1^tm1Ger page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:271542
• Parent Cell Line: AT1 (ES Cell)
• Strain of Origin: 129S2/SvPasCrl

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A neomycin selection cassette replaced exon 2. Western blot analysis confirmed the absence of protein expression in spermatogenic cells. (J:271542)

Expression

In Structures Affected by this Mutation:

2 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Nutm1 Mutation: 36 strains or lines available

References

• Original: J:271542 Shiota H, et al., Nut Directs p300-Dependent, Genome-Wide H4 Hyperacetylation in Male Germ Cells. Cell Rep. 2018 Sep 25;24(13):3477-3487.e6
• All: 1 reference(s)