Fndc5^em21Gpt
Endonuclease-mediated Allele Detail

Summary

• Symbol: Fndc5^em21Gpt
• Name: fibronectin type III domain containing 5; endonuclease-mediated mutation 21, GemPharmatech Co., Ltd
• MGI ID: MGI:6693646
• Synonyms: Fndc5^em21Cd7148
• Gene: Fndc5 Location: Chr4:129030672-129038386 bp, + strand Genetic Position: Chr4, 62.93 cM
• Alliance: Fndc5^em21Gpt page

Mutation origin

• Strain of Origin: C57BL/6JGpt

Mutation description

• Allele Type: Endonuclease-mediated (Null/knockout)
• Mutation: Intragenic deletion
• Mutation details: A 7148 bp genomic region, containing exons 2-6, was deleted using sgRNAs with CRISPR/Cas9 technology. (J:247171)

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Fndc5 Mutation: 18 strains or lines available

References

• Original: J:247171 Liu TY, et al., FNDC5 Alleviates Hepatosteatosis by Restoring AMPK/mTOR-Mediated Autophagy, Fatty Acid Oxidation, and Lipogenesis in Mice. Diabetes. 2016 Nov;65(11):3262-3275
• All: 3 reference(s)