Adam22em1Mafu
Endonuclease-mediated Allele Detail
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Symbol: |
Adam22em1Mafu |
Name: |
a disintegrin and metallopeptidase domain 22; endonuclease-mediated mutation 1, Masaki Fukata |
MGI ID: |
MGI:6693429 |
Synonyms: |
Adam22FAH |
Gene: |
Adam22 Location: Chr5:8122352-8418160 bp, - strand Genetic Position: Chr5, 3.39 cM
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Alliance: |
Adam22em1Mafu page
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Allele Type: |
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Endonuclease-mediated (Epitope tag, Modified isoform(s)) |
Mutation: |
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Insertion
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Mutation details: CRISPR/Cas9 genome editing technology was used to insert an FAH epitope tag after the nucleotide position 696 of the coding sequence. This corresponds to the position between amino acids Val232 and Glu233 of the encoded protein, with the extracellular FAH tag inserted just after the predicted cleavage site of the propolypeptide domain.
(J:300752)
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Mouse strains and cell lines
available from the International Mouse Strain Resource
(IMSR) |
Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available
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Carrying any Adam22 Mutation: |
72 strains or lines available
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Original: |
J:300752 Fukata Y, et al., LGI1-ADAM22-MAGUK configures transsynaptic nanoalignment for synaptic transmission and epilepsy prevention. Proc Natl Acad Sci U S A. 2021 Jan 19;118(3):e2022580118 |
All: |
2 reference(s) |
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