Acvr1b^tm1.1Cfi
Targeted Allele Detail

Summary

• Symbol: Acvr1b^tm1.1Cfi
• Name: activin A receptor, type 1B; targeted mutation 1.1, Carlos F Ibanez
• MGI ID: MGI:6690707
• Synonyms: Alk4^fl
• Gene: Acvr1b Location: Chr15:101071953-101111565 bp, + strand Genetic Position: Chr15, 56.48 cM
• Alliance: Acvr1b^tm1.1Cfi page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:282137
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Conditional ready)
• Mutation: Insertion
• Mutation details: LoxP sites and an frt-flanked neomycin selection cassette were inserted flanking exons 5 and 6, encoding essential regions of the ALK4 kinase domain. The neomycin selection cassette was deleted via FLP1-mediated recombination in the germline, (J:282137)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Acvr1b Mutation: 37 strains or lines available

References

• Original: J:282137 Gongrich C, et al., ALK4 coordinates extracellular and intrinsic signals to regulate development of cortical somatostatin interneurons. J Cell Biol. 2020 Jan 6;219(1)
• All: 2 reference(s)