Rnf157^em1Tmg
Endonuclease-mediated Allele Detail

Summary

• Symbol: Rnf157^em1Tmg
• Name: ring finger protein 157; endonuclease-mediated mutation, Teresa M Gunn
• MGI ID: MGI:6690610
• Gene: Rnf157 Location: Chr11:116227179-116303858 bp, - strand Genetic Position: Chr11, 81.17 cM, cytoband E2
• Alliance: Rnf157^em1Tmg page

Mutation origin

• Strain of Origin: C57BL/6J

Mutation description

• Allele Type: Endonuclease-mediated (Null/knockout)
• Mutation: Intragenic deletion
• Mutation details: CRISPR/Cas9 genome editing technology was used to generate a single nucleotide deletion at each sgRNA target site: a cysteine at position 58 of exon 4 and another cysteine at position 120. (J:299749)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Rnf157 Mutation: 43 strains or lines available

References

• Original: J:299749 Kong JH, et al., A Membrane-Tethered Ubiquitination Pathway Regulates Hedgehog Signaling and Heart Development. Dev Cell. 2020 Nov 23;55(4):432-449.e12
• All: 1 reference(s)