Aplnr^{em4(HBEGF/EGFP,-luc)Smoc}
Endonuclease-mediated Allele Detail

Summary

• Symbol: Aplnr^{em4(HBEGF/EGFP,-luc)Smoc}
• Name: apelin receptor; endonuclease-mediated mutation 4, Shanghai Model Organisms Center
• MGI ID: MGI:6690422
• Synonyms: Apj-DTRGFP-Luc
• Gene: Aplnr Location: Chr2:84966704-84970267 bp, + strand Genetic Position: Chr2, 49.45 cM, cytoband E1
• Alliance: Aplnr^{em4(HBEGF/EGFP,-luc)Smoc} page

Mutation origin

• Strain of Origin: C57BL/6JSmoc

Mutation description

• Allele Type: Endonuclease-mediated (Inserted expressed sequence, Reporter)
• Mutation: Insertion
• Aplnr^{em4(HBEGF/EGFP,-luc)Smoc} expresses 1 gene
  Knock-in expresses:
  

  Organism	Expressed Gene	Note
  Not Specified	Hbegf

• Mutation details: Using the CRISPR/Cas9 technology cDNA encoding DTRGFP fusion protein followed by luciferase was knocked into the endogenous ATG of Aplnr by homologous recombination. (J:270635)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Aplnr Mutation: 29 strains or lines available

References

• Original: J:270635 Zhao H, et al., Apj(+) Vessels Drive Tumor Growth and Represent a Tractable Therapeutic Target. Cell Rep. 2018 Oct 30;25(5):1241-1254.e5
• All: 1 reference(s)